对抗生素和共生素补充剂在试验性死肠炎挑战期间对 brojlers 的生产表现和死肠炎严重性的比较评估
Bikas Raj Shah1, Walid Ghazi Al Hakeem1, Revathi Shanmugasundaram2
1Department of Poultry Science, University of Georgia, Athens, GA, United States.
Frontiers in physiology
|January 30, 2025
概括
在家禽中,协生菌补充剂通过引起免疫反应和减少炎症来管理死肠炎 (NE) 的潜力,尽管它没有改善生长指标. 需要进一步的研究来增强作为抗生素替代品的协生菌疗效.
科学领域:
- 禽畜科学 禽畜科学 禽畜科学
- 动物营养 动物营养
- 免疫学 免疫学 免疫学
背景情况:
- 禽类饮食中的抗生素禁令导致了诸如死肠炎 (NE) 等传染病的增加,造成了重大的经济损失.
- 协生菌为管理家禽健康和生产提供了抗生素的潜在替代品.
- 死亡性肠炎是由诸如Clostridium perfringens之类的病原体引起的,严重影响鸟类福利和农场利能力.
研究的目的:
- 为了比较协生菌和抗生素补充剂在减轻家禽实验诱导的死肠炎的疗效.
- 评估协生菌与抗生素对鸟类表现,死亡率,肠道健康和免疫反应的影响.
- 确定协生菌在家禽生产中作为抗生素生长促进剂的可行替代品的潜力.
主要方法:
- 一项为期35天的研究涉及360只肉,它们被随机分配到四个组:抗生素,挑战+抗生素,共生素和挑战+共生素.
- 使用Eimeria maxima卵和Clostridium perfringens诱导了瘤性肠炎.
- 评估的参数包括体重增加,料摄入量,料转化率,死亡率,肠损伤得分,肠透性和CD4+:CD8+T细胞比率.
主要成果:
- 在NE挑战期间,同生菌和抗生素补充都没有改善体重增加,料摄入量或料转化率.
- 抗生素补充剂在关键挑战期 (14-21天) 中显著降低了死亡率.
- 这两种治疗都未能降低与无挑战组相比的肠道损伤得分,并且协生菌并没有显著降低肠道透性.
结论:
- 协生菌补充剂刺激了免疫反应,减少了肠道炎症,并改善了家禽的死肠炎症状.
- 虽然共生菌作为抗生素的替代品显示出希望,但它们的有效性需要通过优化的配方来提高.
- 对混合益生菌和益生菌进行进一步的研究是必要的,以提高协生菌的性能,以取代家禽行业的抗生素.
相关概念视频
Antimicrobial Effectiveness
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...


