淋巴细胞相关炎症指数在中风后认知障碍中的预测值:系统性审查和元分析
Feng-le Mao1, Xia He2, Xia-Lian Huang2
1School of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Frontiers in neurology
|January 30, 2025
概括
中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 的升高与中风后认知障碍 (PSCI) 有关. 这些标记可能有助于预测PSCI,但HALP得分和淋巴细胞计数没有显示出明确的关联.
科学领域:
- 神经学 神经学
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 脑卒中后认知障碍 (PSCI) 是中风的重要并发症.
- 在预测PSCI方面,炎症指数 (如淋巴细胞相关炎症) 的作用受到争论.
- 需要更新的元分析来澄清这些关联.
研究的目的:
- 对PSCI的淋巴细胞相关炎症指数的预测值进行系统的审查和元分析.
- 评估中性粒细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR) 以及血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 分数与PSCI之间的关联.
主要方法:
- 在六个数据库中进行了系统的文献搜索,截至2024年5月5日,遵守PRISMA指南.
- 数据提取和质量评估 (纽卡斯尔-太华尺度) 是由两个研究人员独立进行的.
- 计算了组合效果大小 (WMD或SMD95%CI),并评估了异质性和出版偏差.
主要成果:
- 对16项研究 (3,406名患者) 的元分析显示,与非PSCI组相比,PSCI组的NLR和PLR水平显著更高.
- 在血红蛋白,白蛋白,淋巴细胞和血小板 (HALP) 评分或淋巴细胞数量之间没有发现统计学上显著的差异.
结论:
- 升高的PLR和NLR与PSCI密切相关,可以作为预测生物标志物.
- 目前的证据不足以确定HALP得分,淋巴细胞计数和PSCI之间的直接关系.
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