长期COVID-19相关和非COVID-19后病毒性嗅觉功能障碍一个比较的MRI研究,重点关注嗅觉裂和灯泡
Yifan Li1,2, Mengfan Liu1,2, Ruoqi Zhang1,2
1Graduate School, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in neurology
|January 30, 2025
概括
长期COVID-19嗅觉功能障碍 (LCOD) 患者与其他后病毒原因相比,嗅觉裂 (OC) 不透明度增加. OC炎症可能会导致持续的气味丧失,这表明有针对性的治疗可以改善结果.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 放射学 放射学是一门学科.
背景情况:
- 持续的嗅觉功能障碍是病毒感染的重要后果,包括COVID-19.
- 区分长期COVID-19相关的嗅觉功能障碍 (LCOD) 和非COVID-19后病毒性嗅觉功能障碍 (NCPVOD) 之间的机制对于有针对性的治疗至关重要.
研究的目的:
- 为了比较嗅觉裂 (OC) 和嗅觉球泡 (OB) 磁共振成像 (MRI) 在LCOD和NCPVOD患者的特征.
- 研究这些群体持续性嗅觉功能障碍的潜在机制.
主要方法:
- 70名嗅觉功能障碍患者 (35名LCOD,35名NCPVOD) 的回顾性分析.
- 嗅觉通路的高分辨率MRI,包括OC不透明度,OB形态和体积.
- 嗅觉心理物理测试 (嗅探棒) 和视觉模拟尺度 (VAS) 用于嗅觉功能.
主要成果:
- 与NCPVOD患者相比,LCOD患者的OC不透明度得分明显高 (p < 0.001).
- 两组之间没有观察到OB形态,信号异常或体积减少的显著差异.
- 在LCOD患者 (p = 0.026) 中,右嗅觉深度较大,与年龄负相关.
结论:
- 在LCOD中增加的OC不透明性表明OC炎症在持续的嗅觉功能障碍中起着作用.
- 向OC炎症可能是改善长期嗅觉结果的治疗策略.
- 在LCOD和NCPVOD中,OB体积减少是常见的发现.
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