基于cystatin C与肌素和心血管-脏-代谢健康的估计球过率之间的差异
Xiaoyan Wu1, Wuming Hu1, Jian Xu1
1Department of Cardiology, Lishui Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China.
Frontiers in medicine
|January 30, 2025
概括
估计的膜过率 (eGFRdiff) 的差异影响心血管-脏-代谢 (CKM) 的健康. 较高的eGFRdiff与CKM综合征患者的较低死亡风险有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 代谢健康 代谢健康
背景情况:
- 囊素C和肌素之间的估计球过速率差异 (eGFRdiff) 是功能障碍的生物标志物.
- eGFRdiff与心血管--代谢 (CKM) 健康的关联及其对CKM综合征患者死亡率的影响仍未得到充分研究.
研究的目的:
- 研究eGFRdiff在CKM健康中的作用.
- 研究eGFRdiff对CKM综合征患者死亡风险的影响.
主要方法:
- 分析了来自国家健康和营养检查调查 (NHANES) 的3622名参与者 (1999-2004).
- 对于CKM健康协会的加权顺序逻辑回归.
- 权重考克斯回归和限制立方线用于死亡风险和剂量反应分析.
主要成果:
- 在eGFRdiff中增加10mL/min/1.73m2与14%降低CKM健康状况较差的几率相关 (cOR=0.86).
- 负的eGFRdiff与所有原因死亡率增加相关 (48%的风险增加),而正的eGFRdiff与风险降低相关 (30%的风险降低).
- eGFRdiff显示了与所有原因 (HR=0.88) 和心血管死亡率 (HR=0.90) 的显著关联.
结论:
- eGFRdiff与CKM健康状况有显著的关联.
- 在CKM综合征患者中,eGFRdiff作为分层死亡风险的有价值生物标志物.
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