代谢功能障碍与脂肪性肝脏和结石相关:正在发生什么?
Owen P Cunneely1, Anne Roberts, Sonia Fargue
1Department of Urology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Current opinion in nephrology and hypertension
|January 30, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 与结石风险增加有关. 潜在的机制包括尿酸和氧酸盐结石,尽管需要进一步的研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 影响了全球近三分之一的人口.
- 结石疾病的发病率与MASLD同时上升.
- 像肥胖,糖尿病,脂质失调,高血压和代谢综合征这样的共同危险因素将这些疾病联系在一起.
研究的目的:
- 审查MASLD和结石疾病之间的关联.
- 探索潜在的相互连接和潜在的机制.
- 突出需要进一步阐明石材特性和驱动因素的需要.
主要方法:
- 对流行病学研究的审查.
- 对潜在的病理生理学联系的分析.
- 检查石块形成的危险因素.
主要成果:
- 关于性别差异的流行病学数据和MASLD对石头风险的影响是相互矛盾的.
- 由于与胰岛素抵抗相关的生产缺陷,MASLD可能通过降低尿液pH来促进尿酸结石.
- MASLD可能通过通过受损的氧酸盐排毒来增强内源性氧酸盐合成,从而增加氧酸盐结石.
结论:
- 与MASLD相关的特定类型的结石需要进一步调查.
- 驱动MASLD-石关联的潜在因素需要澄清.
- 确定了潜在的机制,表明尿酸和酸盐结石的风险增加.
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