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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

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Published on: November 19, 2012

创伤性脑损伤和轻度行为障碍与认知功能和痴呆症的关联

Lisa N Richey¹, Nicholas O Daneshvari², Lisa Young¹

¹Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Journal of geriatric psychiatry and neurology

|January 30, 2025

概括

创伤性脑损伤 (TBI) 不会改变轻度认知障碍 (MCI) 和轻度行为障碍 (MBI) 症状之间的联系. 此外,MBI症状也不会改变患痴呆症的风险,无论TBI状态如何.

科学领域:

神经科学是一个神经科学.
老年学是一门学科.
精神病学是一个精神病学.

背景情况:

轻度行为障碍 (MBI) 呈现出五个关键领域:动机下降,情绪失调,冲动失控,社会不适当性和异常的感知/思想内容.
创伤性脑损伤 (TBI) 可能会使MBI的临床表现复杂化.
了解TBI,MBI和认知状态之间的相互作用对于诊断和管理神经退行性疾病至关重要.

研究的目的:

为了调查轻度认知障碍 (MCI) 和MBI症状关联是否根据TBI状态有所不同.
为了确定MBI域的阳性是否影响TBI病史和没有TBI病史的个体的事件痴呆风险不同.

主要方法:

在社区动脉样硬化风险研究 (平均年龄75.6岁) 中利用了2246名没有痴呆症的参与者的数据.
通过自我报告和医疗规范评估TBI.
通过神经心理测试和告密者采访,使用神经心理 inventory问卷算法评估MBI和认知状态.

主要成果:

在截面上,MCI与MBI的更高几率有关,无论TBI状态如何.
患有MCI的个人,有或没有TBI,表现出更高的动机下降,情感失调和冲动失控的患病率.
从前景来看,MBI阳性与痴呆风险增加有关,没有观察到TBI和没有TBI的人之间有显著差异.

结论:

认知状态和MBI症状之间的关联似乎没有受到TBI的修改.
MBI阳性是发生痴呆症风险的预测因素,独立于TBI史.
需要进一步的研究来澄清TBI,神经精神症状和神经退行过程之间的关系.

关键词:

创伤性脑损伤 (TBI) 是指创伤性脑损伤.痴呆症痴呆症是一种痴呆症.轻度行为障碍轻度行为障碍轻度的认知障碍轻度的认知障碍神经精神病症状神经精神病症状

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