评估病毒病原体的框架:BARDA新兴传染病战略的关键要素
Richard C White1, Gerald Kovacs1, Suchismita Chandran1
1Richard C. White, PhD, is an Interdisciplinary Scientist, Medical Countermeasures Program; Peter L. Adams, PhD, and Karl J. Erlandson, PhD, are Interdisciplinary Scientists, and Ramya Natarajan, PhD, is a Health Scientist, Influenza and Emerging Infectious Diseases Division; Kyla A. Britson, PhD, Rushyannah Killens-Cade, PhD, and Malen A. Link, PhD, are Interdisciplinary Scientists, and Daniel N. Wolfe, PhD, is Deputy Director, Division of Chemical, Biological, Radiological, and Nuclear (CBRN) Countermeasures; Derek L. Eisnor, MD, is a Medical Officer, Division of Clinical Development; Brenda L. Fredericksen, PhD, is Program Director, Nonclinical Research Program, and James Little, MS, is a Senior Scientific Advisor, Division of Nonclinical Development; John S. Lee, PhD, is Program Director, Molecular Diagnostics Program, and Julie M. Villanueva, PhD, is a Scientific Advisor, Detection, Diagnostics, and Devices Infrastructure Division; Kimberly L. Sciarretta, PhD, is Program Director, Launch Office, Division of Research, Innovation, and Ventures; and Robert A. Johnson, PhD, is Director, Medical Countermeasures Program; all at the Biomedical Advanced Research and Development Authority, Washington, DC. Gerald R. Kovacs, PhD, is a Senior Advisor; Huyen Cao, MD, is a Senior Clinical Studies Analyst; Christopher Dale, PhD, and Mark Michalik, MBA, are Senior Subject Matter Experts; Mario H. Skiadopoulos, PhD, is a Preclinical Drug Development Subject Matter Expert; and Xiaomi Tong, PhD, is a Senior Regulatory Affairs Subject Matter Expert; all at Tunnell Government Services, Berwyn, PA. Suchismita Chandran, PhD, is a Lead Associate, and Michael Rowe, MS, is a Senior Consultant; both at Booz Allen Hamilton, McLean, VA. Ethan J. Fritch, PhD, is an ORISE Fellow, Oak Ridge Institute for Science and Education, Oak Ridge, TN. George Robertson, PhD, is Chief Scientific Officer, Cambra Consulting, Inc., Woodbridge, VA.
各国需要更好的流行病准备,包括评估病原体威胁和开发医疗对策 (MCMs). 一个新的工具帮助BARDA利用公共数据管理新兴传染病的MCM开发.
科学领域:
- 公共卫生 公共卫生
- 生物安全是生物安全.
- 传染病的准备工作 传染病的准备工作
背景情况:
- 随着COVID-19的爆发,国家在应对新出现的传染病方面的准备工作出现了严重缺陷.
- 有效的应对需要一个全面的战略,包括威胁评估,医疗对策的快速发展和强大的应对能力.
- 生物医学先进研究和开发局 (BARDA) 在推动针对各种威胁的MCM开发方面发挥着关键作用.
研究的目的:
- 描述BARDA开发的一种新型威胁评估工具.
- 展示该工具如何支持投资组合管理和决策,以开发针对新出现的传染病的MCM.
主要方法:
- 该工具使用易于访问的公共数据和有关病原体威胁的信息.
- 它的设计具有灵活性,允许调整交叉病原体分析的参数.
- 该工具可以更新以纳入新数据,例如新出现的疫情,以完善威胁评估.
主要成果:
- 巴达威胁评估工具为评估病原体风险提供了一个结构化的方法.
- 它有助于在优先考虑和管理MCM开发项目时做出明智的决策.
- 该工具的适应性允许在动态威胁环境中进行持续改进和相关性.
结论:
- 描述的BARDA工具是提高对新出现的传染病的准备能力的宝贵资产.
- 它的数据驱动和灵活的设计支持战略MCM开发和投资组合管理.
- 实施这些工具对于加强国家生物安全和应对能力至关重要.
相关概念视频
Principles of Disease Surveillance
Automated Microbial Diagnostics


