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我们应该移植具有阳性SARS-CoV-2RT-PCR测试的候选人吗?

Ilies Benotmane¹, Nathan Kasriel², Christophe Masset³

¹Department of Nephrology Dialysis and Transplantation, Strasbourg University Hospital, INSERM U1109, Strasbourg, France.

Transplantation

|January 30, 2025

概括

器官移植对于那些阳性SARS-CoV-2测试的患者来说是安全的,如果他们无症状或有轻微的症状. 结果是有利的,在这项对实体器官移植接受者的研究中,没有COVID-19相关的死亡.

科学领域:

移植手术移植手术
传染性疾病传染性疾病
病毒学病毒学

背景情况:

由于免疫抑制风险,对SARS-CoV-2阳性候选人的固体器官移植的安全性尚不确定.
医生在决定是否对SARS-CoV-2阳性个体进行移植时面临挑战.

研究的目的:

评估固体器官移植的安全性和结果,在SARS-CoV-2逆转录聚合酶连锁反应试验阳性患者中.
评估COVID-19对免疫抑制疗法和移植后患者结果的影响.

主要方法:

一项多中心观测研究包括65名肝脏或脏移植候选人,他们的SARS-CoV-2检测结果呈阳性.
收集的数据包括患者人口统计,COVID-19症状,病毒载量 (周期值),血清学和治疗修改.

主要成果:

大多数患者是男性 (62%),平均年龄为55.4岁.
只有2名患者出现症状,3名患者的成像显示与COVID-19相容.
结果总体上是有利的,即使有高的病毒载荷;没有死亡被归因于COVID-19.

结论:

固体器官移植可以安全地在无症状或轻度症状患者中进行,患者的SARS-CoV-2检测结果为阳性.
病史上有SARS-CoV-2感染或免疫,以及令人放心的成像,支持移植的安全性.

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