在吸入麻醉中,气体交换与通风-透气不匹配的双隔间建模的准确性
1Department of Critical Care, Melbourne Medical School, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia; Institute of Breathing and Sleep (IBAS), Heidelberg, Victoria, Australia; Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia.
双隔间肺模型准确地预测了麻醉气体的死亡空间,超过了传统的莱利模型. 这一发现对于了解麻醉期间的气体交换至关重要.
科学领域:
- 麻醉学 麻醉学
- 呼吸系统生理学 呼吸系统生理学
- 计算建模 计算建模
背景情况:
- 气膜通风 - perfusion (V ̇ A / Q ̇) 不同质性解释了麻醉期间的气体交换异常.
- 现有的模型很难准确地预测现代麻醉气体的膜死空间.
研究的目的:
- 为了比较不同的计算模型在预测麻醉期间膜死空间和气体交换时的准确性.
- 用于对传统的瑞利模型进行麻醉气体分析来评估更简单的模型.
主要方法:
- 在29名全身麻醉患者中测量了气体部分压力.
- 双隔间,日志正常和赖利模型被用来预测异花板死空间 (V da / V a) 的异花板,异花板和异花板.
- 模型预测与测量值进行了比较.
主要成果:
- 预测精确的分离器的两模型测量了麻醉气体的气膜死空间 (V da / V aG) (0.539对0.557).
- 传统的莱利模型显著低估了膜死空间 (0.327).
- 没有分流的日志正常和两模型也提供了合理的预测.
结论:
- 准确预测麻醉气体死亡空间需要具有多个肺区的模型.
- 一个简单的两模型有效地捕捉了V̇ A / Q̇散射,以改进气体交换预测.
- 传统的莱利模型对于现代麻醉气体分析是不够的.
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