聚乙烯纳米塑料在肠-大脑轴上车,以加剧帕金森病理学
Xiufang Liang1,2, Gangtong Huang3, Yue Wang1,2
1School of Biomedical Sciences and Engineering, Guangzhou International Campus, South China University of Technology, Guangzhou 510006, China.
ACS nano
|January 30, 2025
概括
聚乙烯纳米塑料通过加速α-synuclein聚合和肠-脑传输,使帕金森病 (PD) 的病理情况恶化. 这导致运动缺陷,强调纳米塑料作为PD的潜在环境风险因素.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- 微型和纳米塑料的暴露是一个日益严重的环境问题,可能会对神经系统产生影响.
- 帕金森病 (PD) 涉及α-synuclein (αS) 聚合和多巴胺能神经元损失,可能与肠-大脑轴相关.
- 布拉克的假设表明PD病理起源于肠道,并通过肠-大脑轴传播到大脑.
研究的目的:
- 为了研究肠道聚乙烯纳米塑料暴露对帕金森病病原体的影响.
- 为了检查纳米塑料对α-synuclein (αS) 聚合和肠到大脑传播的影响.
- 评估纳米塑料在恶化PD类症状和病理中的作用.
主要方法:
- 在体外分析聚乙烯纳米塑料对A53T αS聚合和细胞压力标志物的影响.
- 评估质激活,细胞因子产生,活性氧物种和线粒体/溶酶体完整性.
- 在体内研究涉及纳米塑料和A53T αS在小鼠的同时使用,以评估肠-脑传输和运动功能.
主要成果:
- 聚乙烯纳米塑料在体外加速了A53T αS粉样蛋白聚合.
- 纳米塑料暴露增加了质激活,细胞因子释放和氧化应激,同时损害了线粒体和 lysosomal 功能.
- 纳米塑料和αS在小鼠中的协同肠-脑传输导致了渐进的运动技能缺陷,模仿PD症状.
结论:
- 对聚乙烯纳米塑料的肠道暴露可以加剧帕金森病的病理学.
- 纳米塑料促进αS聚合,并促进它在肠-大脑轴上的运输,从而促进神经退行.
- 这项研究确定纳米塑料是潜在的环境风险因素,影响帕金森病的肠-大脑轴.
相关概念视频
Parkinson's Disease: Overview
451
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
451
Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
Parkinson's Disease: Treatment
194
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
194
EPS and iPS Cells in Disease Research
2.8K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
2.8K
Lysosomal Hydrolases
3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K


