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Updated: Jun 17, 2026

Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain
10:01

Modeling Amyloid-β42 Toxicity and Neurodegeneration in Adult Zebrafish Brain

Published on: October 25, 2017

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在 Zn 的存在下,N-终端截断的 Aβ4-42 在 Aβ1-42 上的明显聚合行为 (II)

Chanju Na1, Mingeun Kim1, Gunhee Kim1

  • 1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

ACS chemical neuroscience
|January 30, 2025
PubMed
概括

在阿尔茨海默病 (AD) 中常见的截断的粉样蛋白-β (Aβ) ,与全长的Aβ聚合不同,特别是当暴露于时. 本研究探讨了这些独特的聚合行为及其对AD病理学的影响.

关键词:
在N端截断的粉样β-β.结合Zn (II) 的特性聚合配置文件的聚合配置文件.金属离子金属离子

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...