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Updated: May 30, 2025

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在小鼠中对RAB11A和RAB11B,小的GTP结合蛋白的分布分析

Yumi Tsuneura1, Tohru Matsuki1, Shima Eda1

  • 1Department of Cellular Pathology, Institute for Developmental Research, Aichi Developmental Disability Center, 713-8 Kamiya, Kasugai, 486-0392, Japan.

Molecular biology reports
|January 30, 2025
PubMed
概括

Rab11A和Rab11B蛋白质在大脑和身体中分布不同,这表明它们在神经发育和突触功能中的作用不同.

关键词:
角辐射质细胞的细胞.大脑发育 大脑发育神经元神经元的神经元在RAB11A中,使用的是RAB11A.在RAB11B中,可以使用RAB11B.突触囊泡中的突触囊泡.

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Rab proteins constitute the largest family of monomeric GTPases, of which 70 members are present in humans. Rab proteins and their effectors regulate consecutive stages of vesicle transport such as vesicle transport, docking, and fusion to the correct recipient membrane.
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Rab GTPases act in a regulated cascade during membrane fusion, helping the lipid bilayers mix. The Rab family of proteins are active when bound to GTP, and inactive when bound to GDP. Hence, they act as guanine nucleotide-dependent molecular switches. Rab-GTP recognizes and binds to long or short-range tethering proteins to capture the target vesicle. These tethers coordinate with SNAREs on the vesicle and the target membrane to assemble the trans SNARE complex that locks the mixing bilayers.
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