持续的偶发性肺亚固体结节的风险评估,以指导适当的监测间隔和终点
Mengwen Liu1, Meng Li1, Hao Feng2
1Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Pulmonology
|January 30, 2025
概括
本研究定义了基于生长风险的肺亚固体结节 (SSN) 的最佳随访间隔. 推的后续计划旨在平衡早期检测,尽量减少对SSNs的不必要监测.
科学领域:
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
背景情况:
- 肺亚固体结节 (SSN) 管理指南各不相同.
- 对SSNs的最佳后续策略需要进一步定义.
研究的目的:
- 为了评估SSNs的增长风险.
- 为SSNs定义适当的后续间隔和停止标准.
- 提出基于5%的增长风险门的后续计划.
主要方法:
- 使用Kaplan-Meier方法来评估SSN增长的直接风险 (IR) 和累积风险 (CR).
- 结节的一致性 (纯磨砂玻璃与部分固体) 和大小是关键因素.
- 分析包括892个SSN (833个纯地玻璃结节[pGGNs],59个部分固体结节[PSNs]).
主要成果:
- 对于pGGNs ≤6.6mm,CR在前9年每3年超过5%.
- 对于6.6-8.8毫米的pGGNs,IR>5%在2-7年;2年的CR在8-9年达到6.66%.
- 对于PSN,IR在4年达到44%的峰值,然后下降.
结论:
- 建议对pGGNs ≤6.6mm.进行9年的三年随访.
- 每年跟踪7年,然后每两年进行2年,对于pGGNs6.6-8.8mm.
- 对于pGGNs>8.8毫米,每年进行7年的随访;对于PSNs,持续每年随访,直到成长为止.
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