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Updated: May 30, 2025

An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
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Published on: February 17, 2023

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准确的基于物理的预测RNA和DNA向质的结合性亲和关系

Ara M Abramyan1, Anna Bochicchio2, Chuanjie Wu3

  • 1Schrödinger Incorporated, San Diego, California 92121, United States.

Journal of chemical information and modeling
|January 30, 2025
PubMed
概括

自由能量扰动 (FEP) 方法准确地预测了对核酸的联体结合亲缘关系. 这种使用FEP+和OPLS4的计算方法有助于发现针对DNA和RNA的抗癌,抗病毒和抗菌剂的药物.

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