接种COVID-19疫苗后的长期甲状腺结果:来自TriNetX网络的2,333,496名患者的队列研究
Kai-Lun Cheng1,2, Wei-Shin Yu1,3, Yu-Hsun Wang4
1School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
The Journal of clinical endocrinology and metabolism
|January 30, 2025
概括
接种COVID-19疫苗可以降低甲状腺功能障碍的风险,但可以增加甲状腺功能障碍的风险. 建议在接种疫苗后持续监测甲状腺功能,特别是对于mRNA疫苗接种者.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 关于COVID-19疫苗接种后长期甲状腺功能障碍的数据有限.
- 了解亚急性甲状腺炎,甲状腺功能障碍和甲状腺功能障碍的风险对于监测接种疫苗的人来说至关重要.
研究的目的:
- 为了评估COVID-19疫苗接种后甲状腺功能障碍的风险.
- 使用大型队列,将接种疫苗的个体与未接种疫苗的个体进行比较.
主要方法:
- 使用TrinetX数据库进行回顾性队列研究 (2022年1月至2023年12月).
- 1,166,748名接种疫苗和1,166,748名未接种疫苗的人.
- 倾向性得分与基线特征平衡相匹配;主要结果:亚急性甲状腺炎,甲状腺功能障碍,甲状腺功能低下.
主要成果:
- 亚急性甲状腺炎的风险保持不变.
- 接种疫苗后3-9个月,甲状腺功能障碍的风险显著降低 (HR 0.65-0.89),但在12个月 (HR 0.99) 后没有显著降低.
- 接种疫苗6-12个月后甲状腺功能低下的风险显著增加 (HR 1.14-1.30);mRNA疫苗接种者在12个月后 (HR 1.16-2.13) 表现出甲状腺功能低下和甲状腺功能低下的风险增加.
结论:
- 接种COVID-19疫苗与减少甲状腺功能障碍和增加甲状腺功能障碍风险有关.
- 这些发现强调了在接种疫苗的人群中需要持续监测甲状腺功能.
- 对于潜在的甲状腺功能改变,需要特别注意mRNA疫苗接种者.
更多相关视频
相关概念视频
The Thyroid Gland
3.5K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.5K
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Vaccinations
43.9K
Overview
43.9K
Immunological Memory
520
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
520
Biological Effects of Radiation
15.3K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.3K


