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与佐莱德酸盐相比,停止使用登苏马布会增加脊椎骨折和死亡风险
Ko-Hsiu Lu1,2, Shiow-Ing Wang3,4, Shun-Fa Yang4,5
1Department of Orthopedics, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
停止使用德诺苏马布 (Dmab) 增加了脊椎骨折 (VF) 和死亡风险,相比于佐勒德罗纳特 (ZOL). 在停止Dmab时,仔细规划至关重要,以减轻这些重大风险.
科学领域:
- 骨质疏松症的管理
- 药物监督 药物监督 药物监督
- 骨健康研究 骨健康研究
背景情况:
- 反弹脊椎骨折 (VFs) 是一个关注后denosumab (Dmab) 撤销.
- 需要有效的策略来停止Dmab.
- 了解Dmab停药后的影响对于患者的安全至关重要.
研究的目的:
- 为了比较denosumab (Dmab) 撤销和zoledronate (ZOL) 停止后的VF风险和全因死亡率.
- 调查Dmab停止后的VF的时间和特征.
- 为临床实践提供有关Dmab停药协议的信息.
主要方法:
- 使用美国TriNetX网络进行的回顾性队列研究.
- 包括50岁以上的骨质疏松症患者,这些患者已停止服用Dmab或ZOL.
- 进行了倾向性得分匹配和生存分析 (Kaplan-Meier,HRs).
主要成果:
- 与佐勒多酸 (ZOL) 组相比,德诺苏玛布 (Dmab) 组的风险明显更高 (HR=1.479) 和所有原因的死亡率 (HR=1.588).
- 在Dmab组中观察到胸部,腰部和崩的VF的风险增加.
- 在Dmab患者中,更高的VF风险在人口学子组和骨折史中一致.
结论:
- 德诺苏马布 (Dmab) 停药与两年内脊椎骨折 (VFs) 的风险增加有关.
- 这种增加的VF风险有助于在停止治疗后整体死亡风险更高.
- 调查结果强调了结构化的Dmab终止计划的必要性,以管理反弹风险基金和死亡率.
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