在寻求帮助的患有皮罗尼病的男性中无子女的风险 - - 瑞典纵向研究
Ralf Kuja-Halkola1, Lars Henningsohn2, Brendan Zietsch3
1Department of Medical Epidemiology and Biostatistics (Solna), Karolinska Institutet, Stockholm, Sweden.
PloS one
|January 30, 2025
概括
皮罗尼氏病 (PD) 可能会影响男性生育孩子的机会. 患有PD的年轻男性患儿不育的风险略高,而老年男性患儿不育的风险略低.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生殖健康 生殖健康
- 男人的健康 男人的健康
背景情况:
- 皮罗尼氏病 (PD) 与生活质量和性福利的降低有关.
- 皮尔斯顿病对生育能力和不育的风险的影响仍未得到充分研究.
- 了解生育结果对于全面的PD患者护理至关重要.
研究的目的:
- 调查皮罗尼病与无子女的风险之间的关联.
- 分析与普通人群相比,诊断为PD的男性的后代的出生率.
- 确定患有PD的男性生育结果的潜在年龄相关差异.
主要方法:
- 使用瑞典国家注册的纵向队列研究.
- 包括大量寻求PD帮助的男性样本和匹配的对照.
- 使用后勤和波松回归模型进行统计分析,以评估无子女和后代率.
主要成果:
- 在35-71岁的患有PD的男性中,不育的可能性略有降低 (OR 0.5-1.0).
- 在35岁或更年轻的PD男性中,无子女的可能性略有增加 (OR 1-1.5).
- 后代率反映了这些趋势,老年男性的患病率更高,年轻男性患病率更低.
结论:
- 皮罗尼氏病可能会影响不育的风险,特别是在年轻男性中.
- 临床实践可以从积极讨论关于PD年轻男性的生育能力中受益.
- 需要进一步的研究,以充分阐明PD与生殖结果之间的关系.
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