成人获得的甲状腺功能低下症,状态和听力损伤:试点研究
Tereza Grimmichova1,2, Ludmila Verespejova3, Zuzana Urbaniova3
1Institute of Endocrinology, Prague, Czech Republic.
PloS one
|January 30, 2025
概括
这项研究发现,在患有甲状腺功能低下症的成年人中,没有听力障碍. 在患者和对照组中,轻微的听力问题是常见的,这表明其他因素也会影响听力健康.
科学领域:
- 内分泌学 在内分泌学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 听力学 听力学是指听力学.
背景情况:
- 甲状腺功能低下,无论是先天的还是获得的,都与听力障碍有关,分别影响35-50%和25%的患者.
- 获得性甲状腺功能低下症中听力缺陷的确切机制,患病率和严重程度仍未得到充分研究.
- 这项研究通过评估获得性甲状腺功能低下症患者的听觉功能来解决知识差距.
研究的目的:
- 研究成年诊断为获得性甲状腺功能低下症的患者听力损失的发生率和特征.
- 探索听力功能,甲状腺功能减退的严重程度和状态之间的潜在相关性.
- 为了比较甲状腺功能低下患者的听觉健康与健康的对照组.
主要方法:
- 招募了30名新诊断的,未经治疗的甲状腺功能低下症患者 (H) 和30名健康对照 (C) 的队列.
- 评估包括生物化学标记物 (甲状腺激素,尿液中),耳视镜,耳 tympanometry,耳声发射 (TOAE),听力测量和脑干听觉唤起潜力 (BERA).
- 统计分析使用了曼-惠特尼U测试,费舍尔的精确测试和多变量回归.
主要成果:
- 与对照组相比,甲状腺下降症患者的甲状腺激素水平 (TSH,ft4) 显著不同 (p < 0.001).
- 对于年龄,尿液中的度或任何听力评估参数 (p > 0.05对所有人来说) 之间没有观察到显著差异.
- 具体来说,自动显微镜,耳计,TOAE,听力计和BERA在甲状腺功能低下和对照组之间没有统计学上显著的差异.
结论:
- 在这项研究中,在患有甲状腺功能低下症的成年人中没有检测到听力障碍.
- 听力障碍与甲状腺功能低下症或状态的严重程度之间没有发现任何关联.
- 轻度听力障碍在甲状腺下降和对照组中普遍存在,这表明多因素对听力健康的影响.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.1K
Functions of Thyroid Hormones
2.5K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.5K
Hearing
51.8K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.8K
Pulmonary Tuberculosis I
220
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
220
Attention-Deficit/Hyperactivity Disorder
36
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
36


