通过人工智能学习生活的语言
1Eric J. Topol is the founder and director of the Scripps Research Translational Institute; executive vice president of Scripps Research; chair of the Department of Translational Medicine at Scripps Research; and the Gary and Mary West Endowed Chair of Innovative Medicine at Scripps Research, La Jolla, CA, USA..
概括
大型生命语言模型 (LLLMs) 正通过整合多原子数据来彻底改变生物学. 这些先进的人工智能模型分析DNA,RNA和蛋白质以了解结构,功能和进化,加速生命科学发现.
科学领域:
- 生物科学
- 人工智能
- 生物信息学
背景情况:
- 蛋白质折叠问题是2021年AlphaFold 2解决的50年难题.
- 在生命科学领域,AlphaFold 2的成功先后引发了大型语言模型 (LLM) 的兴起.
- 最近的进步导致了基础模型的超级加速发展.
研究的目的:
- 突出大型生活语言模型 (LLLMs) 的出现和能力.
- 解释LLLM如何推进对生物分子及其相互作用的理解.
- 展示LLLM与多式模式相比的多态性质.
主要方法:
- 在大量生物数据集上进行预训练的基础模型的开发.
- 在广泛的基因组数据上训练像Evo这样的模型 (例如2,700万的菌体和 prokaryotic基因组).
- 使用人工智能处理和分析各种生物数据类型,包括DNA,RNA和蛋白质序列.
主要成果:
- LLLM可以执行与分子生物学相关的各种任务.
- 这些模型有助于理解蛋白质,RNA,DNA和配体结构,生物学,进化和设计.
- 埃沃模型预测了变体的影响,基因基本性,并产生了新的DNA序列.
结论:
- 对于生命科学来说,LLLM是人工智能的重大飞跃.
- 这些多原子模型为生物研究和发现提供了前所未有的能力.
- 持续发展的LLLM有望进一步加速理解分子层面生命的突破.
相关概念视频
Non-equilibrium in the Cell
4.1K
An important concept in studying metabolism and energy is that of chemical equilibrium. Most chemical reactions are reversible. They can proceed in both directions, releasing energy into their environment in one direction, and absorbing it from the environment in the other direction. The same is true for the chemical reactions involved in cell metabolism, such as the breaking down and building up of proteins into and from individual amino acids, respectively. Reactants within a closed system...
4.1K
Introduction to Learning
326
Learning is the process of acquiring knowledge or skills through practice or experience, leading to long-lasting behavioral changes. This acquisition occurs through interaction with the environment and requires practice or experience. For instance, mastering a skill such as surfing requires considerable practice and experience, highlighting the essential role of repeated interactions with the environment in learning.
In contrast to learned behaviors, unlearned behaviors such as crying, sexual...
In contrast to learned behaviors, unlearned behaviors such as crying, sexual...
326
Cognitive Learning
219
Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
219
Language Development
311
Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...
311
Language and Cognition
318
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
318
Natural and Artificial Concepts
108
In psychology, concepts can be divided into two categories: natural and artificial. Natural concepts are formed through direct or indirect experiences. For example, consider the concept of snow. If you live in a place with regular snowfall, such as Essex Junction, Vermont, you know snow through direct experiences. You’ve seen it fall, touched it, shoveled it, and played in it. You recognize its texture, appearance, and even its smell. In contrast, if you live on an island like Saint...
108


