跨越治疗中断的SIV单克隆抗体给药延迟了的病毒反弹,并选择了逃脱变体
Hannah A D King1,2,3, Daniel Brammer3, Eric Lewitus1,2
1U.S. Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910.
概括
广泛中和抗体 (bNAbs) 显示出治疗HIV-1治疗的潜力. 对的组合单克隆抗体疗法在分析治疗中断期间延迟了病毒反弹并延长了寿命.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 广泛中和抗体 (bNAbs) 对于HIV-1治愈策略至关重要.
- 针对HIV-1包裹 (Env) 的单克隆抗体 (mAbs) 显示出有希望的结果.
- 非人类灵长类动物模型对于评估治疗疗效至关重要.
研究的目的:
- 评估组合单克隆抗体 (mAbs) 对类免疫缺陷病毒 (SIV) 的治疗疗效.
- 在分析性治疗中断 (ATI) 期间评估SIVmac251感染的 rhesus macaques中的mAb组合.
主要方法:
- 通过抗逆转录病毒疗法抑制的SIVmac251感染的 rhesus macaques 没有接受mAb,4mAb组合或2mAb组合.
- 单克隆抗体的剂量为15mg/kg,包括强大的CD4结合点抗体ITS103.01.
- 病毒反弹,病毒病定点,病毒多样性和动物寿命在ATI后进行了监测.
主要成果:
- 与对照组相比,单克隆抗体治疗显著延迟了病毒反弹 (P = 0.0003).
- 4mAb疗法在ATI后3-6周导致反弹;2mAb疗法在5-22周.
- 出现了外包逃生突变,中和了强大的ITS103.01抗体,表明免疫压力.
结论:
- 特定于SIV的单克隆抗体在ATI期间表现出体内抗病毒活性.
- 组合mAb疗法,特别是具有强效抗体的组合疗法,可以影响病毒动态.
- 这些发现支持mAbs作为HIV-1治愈策略的辅助疗法的潜力.
关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒这就是SIV SIV.bNAbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbrhesus 子 子 子 子 子更多相关视频
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