与 pembrolizumab 相关的角膜穿孔 - 一个案例报告与文献评论
Dharshini Balasubaramaniam1, Lim Yi Wen1, Nurul Najieha Amir1
1Universiti Malaya Eye Research Centre (UMERC), Department of Ophthalmology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Ocular immunology and inflammation
|January 30, 2025
概括
布罗利祖马布是一种癌症免疫疗法,可以引起严重的眼部副作用. 本病例报告详细介绍了一名患有无菌角膜和穿孔的患者,在接受pembrolizumab后需要角膜移植.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 布罗利祖马布是一种免疫检查点抑制剂,用于癌症治疗.
- 眼部免疫相关的不良事件 (irAEs) 是pembrolizumab的潜在副作用.
- 早期识别和管理IRE对于患者的治疗结果至关重要.
相关概念视频
01:28Esophageal Perforation-II: Clinical Manifestations and Management
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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
Clinical Manifestations:
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01:22Esophageal Perforation-I: Introduction
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Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
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