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一个模型的zymogene因子XII:洞察到蛋白酶激活

Aleksandr Shamanaev1, Yujie Ma2, Michal B Ponczek3

  • 1Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN.

Blood advances
|January 30, 2025
PubMed
概括

稳定其开放形状的XII因子 (FXII) 突变增强了其通过血卡利克林 (PKa) 的激活. 这导致布拉迪基宁的释放增加,为FXII监管和相关条件提供了洞察力.

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