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同时提取和在现场分离的黄类和类从木叶使用pH响应的深度欧性溶剂/水系统

Ruili Ma¹, Weiguo Wu¹, Yikang Shu¹

¹Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.

|January 30, 2025

概括

研究人员开发了一种新型的pH响应的深溶解剂 (DES) /水系统,用于同时从木叶中提取和分离黄类和类,实现高纯度和可重复使用性.

科学领域:

绿色化学绿色化学
自然产品化学自然产品化学
分离科学分离科学

背景情况:

树叶含有有价值的黄类和类.
传统的提取方法往往缺乏效率和选择性.
这些化合物的同时提取和分离仍然具有挑战性.

研究的目的:

开发一种新型的响应pH的深溶解剂 (DES) /水系统,用于同时提取和在现场分离黄类和类.
确定最佳的DES和条件,以实现高效的提取和分离.
与传统方法相比,评估系统的性能.

主要方法:

综合了五个新的DES.
使用异quercitrin (黄类) 和deoxynojirimycin (类) 的提取和分离效率的评估.
使用最佳的DES,优化提取和pH诱导的相分离条件:[HexA (hexanoic acid) ]][MPD (2-methyl-2,4-pentanediol) ].

主要成果:

最优的DES,[HexA][MPD],促进了同时提取和分离.
在DES阶段 (6.69:1比率) 富含了黄类,而在H2O阶段 (1:9比率) 富含了类.
与传统溶剂相比,[HexA][MPD]/H2O系统的提取效率,纯度和可重复使用性更高.

结论:

响应pH的DES/水系统为自然产品的同时提取和分离提供了一种新且有效的方法.
开发的[HexA][MPD]/H2O系统提供了一种更绿色,更有效的替代方法,用于从木叶中分离黄类和类.
这项研究开创了对pH响应的DES系统在同时提取和分离天然产品中的应用.

关键词:

类化合物是一种类化合物.深度欧性溶剂是一种溶剂.提取提取提取黄类化合物黄类化合物树叶子树叶子响应pH的反应性

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