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在产后的前6个月内自动提供胰岛素 (AiDAPT):预先规定的延伸研究
Tara T M Lee1, Corinne Collett2, Simon Bergford3
1Norwich Medical School, University of East Anglia, Norwich, UK; Diabetes and Antenatal Care, Norfolk and Norwich NHS Foundation Trust, Norwich, UK.
混合闭环 (HCL) 疗法改善了1型糖尿病产后妇女的时间范围. 这种方法在苛刻的分娩后期为标准胰岛素治疗提供了安全有效的替代方案.
科学领域:
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
- 医疗技术 医疗技术 医学技术
背景情况:
- 临床指南缺乏关于产后期混合闭环 (HCL) 胰岛素治疗的具体建议.
- 产后阶段为1型糖尿病的管理带来了独特的挑战,因为新生儿的护理需求.
研究的目的:
- 与标准糖尿病护理相比,评估HCL在产后前六个月使用的安全性和有效性.
- 在产后期间使用HCL疗法评估1型糖尿病妇女的血糖控制.
主要方法:
- 一个多中心,随机对照试验的延伸,对57名患有1型糖尿病的妇女进行了分娩后6个月的跟踪.
- 参与者继续接受指定的治疗:标准胰岛素治疗与持续血糖监测 (CGM) 或HCL治疗 (CamAPS FX).
- 主要结果是时间在范围 (TIR) 的百分比为3.9-10.0 mmol/L.
主要成果:
- 与标准护理相比,HCL组在范围内的平均时间 (72%对54%) 显著更高.
- HCL治疗还导致高血糖减少和平均葡萄糖水平降低,而低血糖率没有显著差异.
- 根据产后期 (0-3个月 vs. 3-6个月) 没有观察到治疗效果的变化,也没有出现安全问题.
结论:
- 混合闭环疗法是安全有效的,用于管理1型糖尿病在产后期.
- 保持70%的时间范围支持在分娩后继续使用HCL而不是标准胰岛素治疗.
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