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流行病学和与产生MBL的肠杆菌相关的结果:一个系统的文献审查

Souha S Kanj¹, Michal Kantecki², Francis F Arhin³

¹Internal Medicine Department, Infectious Diseases Division and Center of for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon.

International journal of antimicrobial agents

|January 30, 2025

概括

产生金属β-乳糖酶 (MBL) 的肠细菌感染是一个越来越令人担忧的问题,治疗选择有限. 本综述强调了它们的全球传播,分子流行病学和相关的临床结果,强调了需要更好的监测.

科学领域:

微生物学与传染病的研究
抗微生物耐药性抗微生物耐药性
流行病学流行病学

背景情况:

产生金属β-乳糖酶 (MBL) 的肠杆菌感染是全球严重的健康威胁,因为治疗选择有限.
了解这些耐药生物体的分子流行病学和地理分布对于有效的控制策略至关重要.

研究的目的:

系统地审查分子流行病学,地理分布和由MBL产生的肠杆菌引起的感染的临床结果.
综合最近文献中的数据,以告知公共卫生响应和抗微生物药物管理工作.

主要方法:

对2013年1月至2023年5月期间发表的研究进行系统性文献综述.
纳入标准:使用≥25个产生MBL的肠杆菌分离物和≥2个明确的结果的研究.
数据提取集中在MBL类型,地理来源,抗菌素敏感性,临床结果和风险因素上.

主要成果:

总共包括了39项研究,主要来自亚洲和欧洲.
新德里金属β-乳糖酶 (NDM) 生产者是最常见的 (85.6%),特别是NDM-1变种.
产生MBL的患者对大多数抗微生物药物的敏感性降低,除了胆固醇素和tigecycline,并与更长的住院时间和显著的死亡率 (18.8%-57.0%) 相联系.

结论:

产生MBL的肠杆菌感染很普遍,NDM变种在全球占主导地位.
这些感染与高死亡率和发病率有关,强调迫切需要加强监测和感染控制措施.
对于了解感染负担和防止进一步传播,对MBL患病率的一致报告至关重要.

关键词:

耐卡巴胺的肠道细菌产生碳酶的肠道细菌.进入细菌体中的细菌.流行病学流行病学金属-β-乳酸酶是一种金属-β-乳酸酶.结果的结果.

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