生物活性的治疗潜力对尼罗河的乳球菌 petauri 在尼罗河
Daiane Vaneci-Silva1, Daniel de Abreu Reis Ferreira2, André do Vale Oliveira1
1São Paulo State University (UNESP), Aquaculture Center of UNESP, Laboratory of Microbiology and Parasitology of Aquatic Organisms, Jaboticabal, São Paulo, 14884-900, Brazil.
Microbial pathogenesis
|January 30, 2025
概括
一种新型的生物活性有效治疗尼罗河鱼中的Lactococcus petauri感染,为水产养殖健康提供了传统抗微生物药物的有希望的替代品. 这种可以降低死亡率,并防止细菌的持久性.
科学领域:
- 水生动物的健康状况.
- 细菌学 细菌学是一门学科.
- 抗菌研究中的抗菌研究.
背景情况:
- 由Lactococcus petauri引起的游泳池乳球菌病是水产养殖中一个重要的新兴疾病,导致大量的死亡率.
- 越来越多地使用抗微生物药物,需要探索鱼类细菌感染的替代治疗方法.
- 尼罗河鱼 (Oreochromis niloticus) 容易感染L. petauri,这会影响水产养殖的生产力.
研究的目的:
- 为了确定尼罗河鱼死亡爆发的致病原体.
- 为了评估分离的细菌的致病性.
- 为了评估生物活性和florfenicol对乳球球菌 petauri感染的治疗疗效.
主要方法:
- 从患病的尼罗河鱼中分离和识别细菌.
- 在健康的尼罗河鱼中使用科赫的假设进行致病性测试.
- 组织病理学分析以确定组织损伤.
- 与未经治疗的对照组相比,接受生物活性 (胃口/注射) 或佛罗芬尼科尔的实验治疗组.
主要成果:
- 牛乳球菌被确定为尼罗河鱼死亡率的病原体.
- 接种引发了临床症状和严重的组织病理病变,证实了高毒性.
- 与未经处理的鱼 (6.7%) 相比,生物活性治疗 (口腔和注射) 显著增加了生存率 (36.85%和26.44%).
- 通过或注射用生物活性治疗的鱼类中消除了细菌持久性.
结论:
- 已发现的细菌Lactococcus petauri对尼罗河鱼有高度的毒性.
- 商用生物活性显示出对L. petauri感染有显著的治疗效果.
- 生物活性代表了水产养殖中常规抗微生物药物的可行和有效替代品,用于治疗L. petauri感染.
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