一个简单的方法来制造基托桑输送的阿弗梅克丁受控释放微粒,以提高疗效和减少残留物
Xiang-Ping Kong1, Wei-Kun Li1, Jun-Hao Liu2
1College of Chemistry and Pharmacy, Qingdao Agricultural University, Qingdao 266109, Shandong, PR China.
International journal of biological macromolecules
|January 30, 2025
概括
使用奇托 (CTS) 控制释放的阿弗梅克丁 (AVM) 微粒体显示出协同作用,增强害虫控制效率并减少杀虫剂的使用. 这种可持续的方法提供了更好的快速和长期的害虫管理.
科学领域:
- 农业科学 农业科学
- 材料科学 材料科学 材料科学
- 昆虫学 昆虫学是一门学科.
背景情况:
- 控制释放配方对于提高杀虫剂有效性和减少对环境的影响至关重要.
- 载体和杀虫剂之间的协同作用可以提高害虫控制性能.
- 阿弗梅克丁 (AVM) 是一种广泛使用的杀虫剂,而奇托 (CTS) 是一种生物相容的聚合物载体.
研究的目的:
- 为了制造控制释放的微粒的avermectin使用奇托作为载体.
- 为了研究基托和阿弗梅克丁之间的协同效应,以加强害虫控制.
- 评估AVM@CTS微粒对Plutella xylostella的疗效和环境命运.
主要方法:
- 通过pH调整方法制造AVM@CTS微粒.
- 微粒的特征,包括封装效率,光稳定性和pH/温度敏感性.
- 使用仪器检测和分子动力学模拟来评估AVM-CTS相互作用.
- 在体外释放研究和对Plutella xylostella幼虫的毒性测试.
- 在土壤中评估AVM@CTS微粒子降解.
主要成果:
- 高封装效率 (73.3%) 和AVM@CTS微粒的良好沉积行为.
- 通过物理吸附,粘附和弱H键,AVM与CTS相互作用.
- 控制释放配方遵循了第一阶动力学.
- 在CTS和AVM之间具有显著的协同作用,导致对Plutella xylostella的优越快速作用和长期疗效.
- 与AVM溶液相比,AVM@CTS的LC50 (12.73 mg/L) 降低,土壤半衰期更短 (19.6天).
结论:
- 奇托是阿弗梅克丁的有效载体,产生具有协同作用的受控释放系统.
- 在AVM@CTS微粒显示增强的有效性和改善的环境特征,以实现可持续的害虫控制.
- 这项研究为开发具有载体-杀虫剂协同作用的先进控制释放系统提供了基础.
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