甘油三糖指数与中国钢铁工人动脉样硬化之间的关联:一个横截面研究
Haoyue Cao1, Qinglin Li2, Juxiang Yuan3
1School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New City, Tangshan City, 063210, Hebei Province, China.
Scientific reports
|January 30, 2025
概括
甘油三糖 (TyG) 指数与中国钢铁工人患动脉样硬化 (CAS) 的风险较高有关. 一个TyG指数大于8.72表明CAS风险增加,建议针对这一群体进行查和干预.
科学领域:
- 心血管研究研究心血管研究
- 职业健康 职业健康 职业健康
- 生物标志物发现发现
背景情况:
- 动脉样硬化 (CAS) 构成严重的健康风险,特别是在职业环境中.
- 确定可靠的生物标志物用于早期CAS检测对于有效的预防策略至关重要.
- 钢铁工人可能面临独特的职业暴露,影响心血管健康.
研究的目的:
- 研究中国钢铁工人中甘油三糖 (TyG) 指数与动脉样硬化 (CAS) 风险之间的关联.
- 评估TyG指数在这个特定职业群体中对CAS的预测能力.
- 探索职业危险对TyG指数和CAS之间的关系的影响.
主要方法:
- 一项涉及4203名中国钢铁工人的横截面研究.
- 使用禁食甘油三和葡萄糖水平计算TyG指数.
- 通过多变量逻辑回归和受限立方线模型分析CAS与TyG指数的关联.
- 基于性别,年龄,生活方式,病史和职业暴露的子组分析.
- 校准,风险重新分类,LASSO回归和用于预测建模的机器学习.
主要成果:
- 泰格指数的最高四分位数与CAS (OR:3.199) 的增加几率,动脉内膜介质厚度 (CIMT) 的增加以及斑块的存在显著相关.
- 在TyG指数和CAS风险 (P <0.05) 之间观察到非线性正相关性,风险在TyG> 8.72以上升级.
- 职业危险暴露与更高的CAS风险有关.
- 泰格指数表明,除了传统的风险因素之外,CAS的额外预测价值显著.
结论:
- TyG指数是评估中国钢铁工人中CAS风险的有价值和实用的预测工具.
- 钢铁工人的TyG指数大于8.72的钢铁工人需要加强CAS查和及时进行健康干预.
- 职业危险暴露是CAS对钢铁工人风险评估的一个重要考虑因素.
- 泰格指数提供了一种简单,快速和可靠的方法,用于识别该人群中CAS高风险个体.
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