儿童肥胖和多发性硬化症的风险:全国性的前性队列研究
Emilia Hagman1, Resthie R Putri2, Pernilla Danielsson2
1Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, S-141 57, Huddinge, Sweden. emilia.hagman@ki.se.
International journal of obesity (2005)
|January 30, 2025
概括
高的儿科体重指数 (BMI) 会增加多发性硬化症 (MS) 的风险,特别是在严重肥胖的情况下. 早期预防是关键的,因为肥胖治疗反应在本研究中没有改变MS风险.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 新出现的证据将儿科肥胖与多发性硬化症 (MS) 风险增加联系在一起.
- 以前的研究表明,这种联系仅限于青少年肥胖,而不是儿童肥胖.
研究的目的:
- 评估儿科肥胖症与患MS的风险之间的关联.
- 调查肥胖症的严重程度和治疗开始时的年龄是否会影响MS风险.
- 检查肥胖症治疗反应对小组中MS风险的影响.
主要方法:
- 一项前性队列研究涉及来自瑞典儿童肥胖治疗登记册 (BORIS) 的21,652名2-19岁的个人和102,187名匹配的一般人口比较者.
- 通过国家患者登记册识别MS.
- 对父母成员国进行调整的危险比率 (HR) 的计算.
主要成果:
- 儿科肥胖队列显示患MS的风险增加了2.28倍 (HR 2.28;95% CI 1.45-3.58).
- 观察到剂量反应关系,较高的肥胖类 (II类:HR 3.42;1.89-6.19) 与MS风险的关联比I类 (HR 1.34;0.64-2.81) 更强.
- 儿童 (HR 3.16; 1.12-8.87) 和青少年肥胖 (HR 2.12; 1.28-3.51) 都与MS风险增加有关. 降低的BMI和SDS并没有降低MS的可能性 (HR1.09;0.92-1.29,每0.25单位降低).
结论:
- 儿童和青少年肥胖都与患MS的风险增加有关.
- 肥胖严重程度和未来的MS风险之间存在剂量反应关系.
- 对小儿肥胖治疗的反应没有影响这种关联,这强调了早期预防肥胖的重要性.
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