尼沃卢马布诱导的脑膜炎的临床特征,治疗和结果
Zhaoquan Wu1,2, Wei Sun3, Binsheng He1,2
1College of Pharmacy, Changsha Medical University, Changsha, Hunan, China.
Immunopharmacology and immunotoxicology
|January 30, 2025
概括
尼沃卢马布可以引起眼膜炎,一种眼睛炎症,通常在5个月内出现. 在大多数患者中,早期识别和皮质类固醇治疗导致显著改善.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 尼沃卢马布是一种免疫检查点抑制剂,与脑膜炎有关.
- 尼沃卢马布诱导的脑膜炎的临床特征尚不清楚.
研究的目的:
- 为了描述尼沃卢马布诱导的脑膜炎的临床表现.
- 为预防,诊断和治疗提供指导.
主要方法:
- 对从2000年到2024年9月的病例报告进行了回顾性分析.
- 包括来自中文和英语数据库的案例.
主要成果:
- 分析了38名患有尼沃卢马布诱导的脑膜炎的患者.
- 平均年龄为63岁;发病时间从1周到24个月.
- 视力模糊是常见的;42.1%的人类似于Vogt-Koyanagi-Harada疾病.
- 最常见的是先前的脑膜炎 (52.6%).
- 89.2%的人有双边参与.
- 皮质类固醇治疗导致平均4周的改善.
结论:
- 尿道炎是尼沃卢马布的一个罕见但可治疗的不良反应.
- 症状通常发生在治疗5个月内.
- 及时诊断和管理对于有利的结果至关重要.
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