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神经素1通过ERK/SIRT1信号通路改善与代谢功能障碍相关的脂肪肝疾病

Chengan Xu¹, Shouhao Wang², Di Meng³

¹Center for General Practice Medicine, Department of Infectious Diseases, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.

BMC gastroenterology

|January 30, 2025

概括

神经调节蛋白-1 (NRG1) 通过激活ERK/SIRT1信号,改善肝脏健康并减少亡来保护MAFLD. 这一途径突出显示NRG1作为MAFLD的潜在治疗点.

科学领域:

生物化学生化学
细胞生物学细胞生物学
肝病学肝病学是一种肝病学.

背景情况:

神经调节素 (NRG) 家族参与能量代谢.
NRG1在MAFLD细胞中起着保护作用,但其确切的机制尚不清楚.
这项研究研究了NRG1通过ERK/SIRT1信号传递在MAFLD病变发生过程中的作用.

研究的目的:

阐明NRG1在MAFLD中具有保护作用的机制.
调查ERK/SIRT1信号通路的参与.
探索NRG1作为MAFLD的潜在治疗策略.

主要方法:

使用高脂肪饮食诱导的MAFLD小鼠模型和油脂/棕酸诱导的HepG2细胞模型.
在体内和体外给予NRG1和ERK抑制剂PD98059.
评估了组织病理学变化,生化标志物,炎症因素,脂质代谢,亡和自.

主要成果:

在MAFLD模型中,NRG1表达显著降低.
NRG1治疗改善了肝硬化症,增强了细胞活力,减少了细胞亡,减轻了肝损伤.
NRG1提高了ERBB2,ERBB3,p-ERK1/2,SIRT1,p-FOXO1和LC3II/I比率,同时降低了SREBP1c;这些效应被PD98059.9扭转.

结论:

NRG1通过通过ErbB2-ErbB3信号激活ERK1/2来保护MAFLD.
这种激活促进SIRT1表达和自,缓解MAFLD的进展.
NRG1代表了MAFLD治疗的有前途的治疗标.

关键词:

自自是一种自的过程.埃尔克·埃尔克是什么意思与代谢功能障碍相关的脂肪肝疾病.神经调节素 1 神经调节素 1 一个SIRT1系统.

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