流行病应对研究中的队列保留:SARS-CoV2免疫和再感染评估 (SIREN) 研究的教训
Anna Howells1, Katie Munro2, Sarah Foulkes2
1United Kingdom Health Security Agency (UKHSA), London, UK. anna.howells@wales.nhs.uk.
BMC medical research methodology
|January 30, 2025
概括
在SIREN医疗保健工作者研究中的高保留率表明了大队列研究在流行病期间的可行性. 专注于参与和降低障碍的战略在24个月内保持了参与者的参与.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染病研究 传染病研究
背景情况:
- 该SIREN研究是一个大型的医疗保健工作者队列,评估了英国135个组织的COVID-19发病率,免疫力和疫苗有效性.
- 在大流行期间进行密集的前性研究提出了重大挑战.
- 一个不断发展的保留计划是使用减少障碍,社区建设,后续和追踪的最佳实践来开发的.
研究的目的:
- 在SIREN研究中评估12个月和24个月的队列保留率.
- 识别影响参与者留守和退出因素.
- 为未来的流行病准备和医疗保健工作者研究提供学习.
主要方法:
- 在12个月和24个月 (2020年6月 - 2023年3月) 的队列保留的混合方法评估.
- 后勤回归用于根据人口统计和地点分析保留.
- 通过调查收集的参与者退出原因;通过在线调查和重点小组收集的反.
主要成果:
- 37,275名参与者中有84.7%完成了12个月的随访;12,635名参与者中有85.5%完成了24个月的随访.
- 随着年龄的增长,保留率随着年龄的增长而增加,与白人参与者相比,亚裔和黑人族群的保留率更高.
- 退出的主要原因包括工作负担,离职以及医疗问题.
结论:
- 在SIREN研究中24个月的高参与者保留率证实了大型队列研究作为流行病研究工具的可行性.
- 在急性流行病应对期间,可以保持医疗保健工作者的参与队列.
- 这些发现为流行病准备和未来的医疗保健工作者研究提供了宝贵的见解.
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