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艾滋病毒感染者与未感染者之间的SARS-CoV-2感染和影响因素的差异

Jianhui Yang¹, Esben Strodl², Dandan Zhang¹

¹Ningbo Municipal Centre for Disease Control and Prevention, 1166 Fanjiang'an Road, Haishu District, Ningbo City, 315016, Zhejiang Province, PRC, China.

BMC public health

|January 30, 2025

概括

艾滋病毒感染者 (PLWH) 感染SARS-CoV-2的风险较低,但长期出现COVID-19症状的风险更高. 抗逆转录病毒疗法 (ART) 增加了PLWH患者的SARS-CoV-2感染风险,而疫苗则减少了HIV阴性个体的长期症状.

科学领域:

传染性疾病传染性疾病
公共卫生公共卫生
免疫学免疫学免疫学

背景情况:

关于艾滋病毒状况和COVID-19风险的研究结果各不相同.
这项研究调查了中国的HIV感染特征和COVID-19风险.

研究的目的:

估计艾滋病毒感染特征与COVID-19风险之间的关联.
为了比较PLWH和HIV阴性个体之间的SARS-CoV-2感染和延长的核酸转化时间.

主要方法:

在中国宁波,对1995名艾滋病毒感染者 (PLWH) 和3503名艾滋病毒阴性成年人的横截面调查.
与SARS-CoV-2感染流行率和长时间核酸转化时间的比较.
探索SARS-CoV-2感染和延长转化时间的风险因素.

主要成果:

PLWH的SARS-CoV-2感染率 (74.4%) 比HIV阴性个体 (81.8%) 低.
PLWH显示核酸转化时间延长的风险较高 (29.4%与22.7%相比).
在PLWH中,ART使用增加了SARS-CoV-2感染风险;在HIV阴性个体中,COVID-19疫苗接种减少了长期转化时间.

结论:

艾滋病毒状况与SARS-CoV-2感染和延长转化时间有显著的关联.
在PLWH中需要对ART和COVID-19疫苗的影响进行进一步的研究.

关键词:

艺术艺术艺术艺术关于COVID-19疫苗的使用情况艾滋病病毒艾滋病病毒艾滋病病毒这就是Omicron.这就是SARS-CoV-2病毒.长时间的核酸转化时间.

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