儿童时期唐氏综合征的牙周病:一个范围审查
Valentin Vergier1,2, Anne-Margaux Collignon3,4, Marjolaine Gosset3,4
1Université Paris Cité, Laboratory URP 2496 Orofacial Pathologies, Imaging, and Biotherapies, Faculty of odontology, Montrouge, France. valentin.vergier@u-paris.fr.
BMC oral health
|January 30, 2025
概括
患有唐氏综合征 (DS) 的儿童表现出牙周炎症的增加,但没有骨质损失. 了解这种炎症有助于了解DS患者的免疫失调.
科学领域:
- 口腔健康 口腔健康
- 遗传学 遗传学是一种遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 唐氏综合征 (DS) 与免疫失调和前炎症状态有关,影响感染反应.
- 牙周炎是一种常见的炎症性疾病,会影响患有DS的成人和青少年,但其在患有DS的儿童中的患病率尚不清楚.
- 本综述解决了DS儿童牙周炎的知识差距,并探讨了潜在的免疫机制.
研究的目的:
- 系统地审查有关唐氏综合征儿童牙周炎的现有文献.
- 调查牙周病在这个人群中的患病率和严重程度.
- 探索潜在的与免疫相关的机制,有助于DS儿童牙周炎.
主要方法:
- 从1951年到2024年7月的研究进行了系统的范围审查,搜索PubMed/MEDLINE和谷歌学者.
- 纳入标准侧重于以英语或法语为基础的关于DS儿童牙周炎的初级研究,不包括评论,动物研究和其他残疾研究.
- 使用纽卡斯尔-太华尺度和针对案例报告/系列的特定工具来评估证据质量.
主要成果:
- 在2431篇最初的文章中,包括58项研究 (横截面,病例控制,队列,病例报告/系列).
- 与对照组相比,患有DS的儿童表现出更严重的牙周炎症,但关于骨质损失的证据是不确定的.
- 局部风险因素并不显著;炎症增加可能源于DS的一般炎症前体型.
结论:
- 患有唐氏综合征的儿童似乎经历了高度的牙周炎症,而没有显著的骨质损失.
- 对DS儿童牙周炎症的进一步研究可以揭示这种遗传疾病中的免疫功能放松调节.
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