乳酸菌 (Lactobacillus gasseri LGV03) 衍生因道尔-3-乳酸通过激活烯碳化合物受体来改善免疫反应
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Updated: May 1, 2026

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Published on: January 27, 2019
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Zikang Zhang1, Kangdi Zheng2, Zhao Zhang2
1Department of Laboratory Medicine, The Seventh Affiliated Hospital of Southern Medical University, Foshan, Guangdong, 528244, China.
Microbial cell factories
|January 30, 2025
概括
乳酸菌 (Lactobacillus gasseri LGV03) 通过产生英多尔-3-乳酸来增强免疫反应,从而激活基碳水化合物受体 (AHR) 途径. 这种益生菌可能有助于缓解免疫抑制并促进细胞因子的产生.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 女性生殖道的微生物群影响宿主的免疫防御.
- 乳酸菌毒素LGV03 (L. gasseri LGV03) 有助于HPV清除并调节免疫反应.
- 需要阐明L. gasseri LGV03免疫调节作用的精确机制.
研究的目的:
- 在斑马鱼模型中研究L. gasseri LGV03的免疫调节活性.
- 为了确定负责L. gasseri LGV03免疫增强作用的特定分子.
- 阐明L. gasseri LGV03介导的免疫调节中涉及的信号通路.
主要方法:
- 采用了斑马鱼中性缺血和免疫细胞缺陷的模型.
- 进行了转录组测序,以分析基因表达变化.
- 非向的代谢基因组确定了L. gasseri的关键代谢物LGV03.03.
- 使用Ect1/E6E7细胞和酸受体 (AHR) 抗剂进行了体外测定.
主要成果:
- 在斑马鱼中,L. gasseri LGV03改善了药物诱导的中性质衰竭和免疫细胞缺陷.
- 观察到TNF-α,TNF-β和IFN-αmRNA的显著增加.
- 在L. gasseriLGV03.03中发现了印衍生物,特别是印-3-乳酸.
- 印度尔-3-乳酸模仿了L. gasseri LGV03的保护作用,这些保护作用依赖于AHR.
结论:
- L. gasseri LGV03 显示出强大的免疫调节能力.
- 印度尔-3-乳酸是L. gasseri LGV03增强免疫力的关键媒介.
- 基碳化合物受体 (AHR) 途径对于L. gasseri LGV03对免疫功能的有益作用至关重要.
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