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成年活体供体肝移植后的异种移植耐受性:一个病例控制研究

Mohamed S Habl¹, Moataz Maher Emara², Reham A Zayed¹

¹Department of Hepatology and Gastroenterology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

|January 30, 2025

概括

肝移植后的免疫耐受性是常见的,发生在接受者的74.7%. 关键预测因素包括MELD得分,移植指示,以及排斥或肝炎等并发症.

科学领域:

肝病学肝病学是一种肝病学.
移植免疫学移植免疫学
临床医学临床医学

背景情况:

研究成年活体供体肝移植 (LDLT) 接受者的免疫耐受性.
了解免疫耐受性的发生率和预测因素对于移植后的管理至关重要.

研究的目的:

为了确定成年LDLT受体中免疫耐受性的发生率.
确定与在LDLT后实现免疫耐受性相关的潜在预测因素.

主要方法:

对368名成人LDLT接受者的病例控制研究,随访时间≥5年.
组1:达到耐受性 (运行或正常) ≥1年. 第二组:没有达到耐受性.
后勤回归分析以确定耐受性的预测因素.

主要成果:

在74.7%的接受者 (275/368) 中观察到全移植耐受性.
耐受性组的年龄较高;肝酶和胆红素水平较低.
在耐受性组中,急性细胞排斥 (ACR),复发性病毒性肝炎和胆道并发症的发生率降低.

结论:

在绝大多数LDLT受体中,可实现全移植耐受性.
手术前的MELD得分,肝移植 (LT) 的适用性,ACR,复发性病毒性肝炎和胆道并发症是全移植耐受性的重要预测因素.

关键词:

整体移植的宽容度移植器的拒绝移植器的拒绝免疫抑制是一种免疫抑制.活体捐赠者肝脏移植手术

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