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报告和代表参与者种族和民族在III期临床试验固体瘤的代表

Tianyi Wang¹, Dinorah J Villanueva², Ambily Banerjee³

¹Janssen Research & Development LLC, Raritan, NJ, USA.

Future science OA

|January 31, 2025

概括

种族和少数民族参与癌症临床试验的情况正在改善,但仍然不足. 现实世界的数据可以帮助制定招聘目标,以提高瘤学研究的多样性.

科学领域:

在瘤学瘤学.
健康公平卫生公平
临床试验多样性临床试验多样性

背景情况:

在临床试验中纳入种族和民族少数群体对于健康公平至关重要.
当前的临床试验人口统计数据往往不反映更广泛的患者群体.

研究的目的:

评估种族和民族少数群体在癌症临床试验III阶段的报告和招生情况.
将试验参与者的人口统计数据与参考人口数据进行比较.

主要方法:

在国家医学图书馆的临床试验数据库中搜索了III期肺癌,结肠直肠癌,乳腺癌和前列腺癌试验.
利用监测,流行病学和最终结果 (SEER) 数据库来获得参考人口人口统计数据.

主要成果:

在181项试验中,分别报告了86.7%和60.2%的种族和民族数据,随着时间的推移,趋势呈现出改善.
与SEER数据相比,白人参与者占主导地位 (76.3%),亚洲/太平洋岛民,黑人/非洲裔美国人和美洲印第安人/阿拉斯加土著人的代表性较低.
少数群体的入学率从2011年之前的19.4%增加到2015年后的26.2%,但在特定的癌症类型和少数群体之间仍然存在差异.

结论:

虽然在临床试验中种族和民族少数群体的报告和招生情况正在改善,但仍然不足.
需要使用现实世界的数据进行进一步的研究,以确定有针对性的招聘目标,并通过了解患者的地理分布来增强多样性.

关键词:

种族种族种族种族在 SEER 计划中,临床试验临床试验临床试验临床试验临床试验民族身份民族身份这些都是新生儿瘤.

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