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Updated: May 30, 2025

Simultaneous Measurement of HDAC1 and HDAC6 Activity in HeLa Cells Using UHPLC-MS
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开创了第一类HDAC-ROCK抑制剂作为潜在的多目标抗癌剂

Milan Beljkas1, Dusan Ruzic1, Ana Djuric2

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.

Future medicinal chemistry
|January 31, 2025
PubMed
概括

这项研究引入了针对胰岛素脱乙酶 (HDAC) 和Rho相关蛋白激酶 (ROCK) 的新型双重抑制剂,用于癌症治疗. 化合物C-9在胰腺癌和乳腺癌模型中显示出强大的抗癌和抗转移效应.

关键词:
希斯脱乙酶的使用情况罗关联蛋白激酶 (rho-associated protein kinases) 是一种与蛋白质相关的酶.乳腺癌 乳腺癌 乳腺癌多目标导向的带.胰腺管道腺癌瘤

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