探索胎盘微生物组的组成及其在早产中潜在的起源
Marwa Saadaoui1, Mohamed Nadhir Djekidel1, Selvasankar Murugesan1
1Research Department, Sidra Medicine, Doha, Qatar.
Frontiers in cellular and infection microbiology
|January 31, 2025
概括
胎盘微生物组在健康和早产怀孕之间有所不同. 在早产中,胎盘类似于阴道微生物组,而在预产中,它类似于口腔微生物组.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 基因组学就是基因组学.
背景情况:
- 胎盘在历史上被认为是无菌的,但最近的研究表明有一个独特的胎盘微生物组.
- 胎盘微生物组对怀孕和胎儿健康的起源和影响尚未完全理解.
- 同一个队列内的阴道,口腔和胎盘微生物组的研究有限,特别是关于早产 (PTB) 的研究.
研究的目的:
- 研究患有PTB和结核病 (TB) 的妇女口腔和胎盘微生物组的组成.
- 探索胎盘微生物组 (口腔与阴道) 的潜在起源.
- 为了确定胎盘微生物组的组成是否在健康和复杂妊娠 (PTB) 之间有所不同.
主要方法:
- 使用16S rRNA基因测序分析了口腔和胎盘微生物组合.
- 从18名患有PTB的妇女和36名结核病的匹配对照妇女收集了样本.
- 从同一个队列中,利用了以前发表的阴道微生物组数据.
主要成果:
- 在PTB和TB组之间观察到明显的口腔微生物组概况,在PTB中更丰富的特定细菌 (例如Treponema maltophilum).
- 胎盘微生物组是由Firmicutes, Bacteroidetes,Actinobacteria和Proteobacteria主导的.
- 在PTB病例中,胎盘微生物组与阴道微生物组的相似性更大,而在结核病例中,它与口腔微生物组相似.
结论:
- 胎盘微生物组可能来自口腔或阴道来源.
- 在PTB病例中增加了阴道 - 胎盘微生物交叉声.
- 在PTB怀孕中,特定的微生物概况可以作为潜在的生物标志物.
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