相关实验视频

Updated: May 30, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

评估抗PD-1免疫疗法与IMRT结合在鼻癌中对甲状腺功能障碍的影响

Liqianqi Chen¹, Zihuang Li¹, Xianming Li¹

¹The Second Clinical Medical College of Jinan University, Department of Radiotherapy, Shenzhen People's Hospital, Shenzhen, Guangdong, China.

Frontiers in immunology

|January 31, 2025

概括

针对鼻癌 (NPC) 的抗PD-1免疫疗法可以导致甲状腺功能障碍. 将免疫疗法与强度调节放射疗法 (IMRT) 结合起来,会增加甲状腺问题的风险和严重程度,特别是在有甲状腺结节或吸烟史的患者中.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
内分泌学在内分泌学.

背景情况:

抗PD-1免疫疗法改善了鼻癌 (NPC) 患者的治疗结果.
与免疫相关的不良反应 (irAEs) 是常见的,甲状腺功能障碍是经常关注的问题.
抗PD-1免疫疗法,强度调节放射疗法 (IMRT) 和甲状腺功能之间的相互作用需要进一步研究.

研究的目的:

分析接受抗PD-1免疫治疗的NPC患者甲状腺功能障碍的发生率和危险因素.
评估结合抗PD-1免疫疗法与IMRT对甲状腺功能的影响.
探索放射治疗和免疫相关甲状腺不良反应之间的潜在相互作用.

主要方法:

对108名NPC患者的回顾性分析,这些患者接受了抗PD-1免疫疗法与化疗或化疗放射治疗相结合的治疗.
收集临床数据,包括吸烟状态,BMI,甲状腺结节,分期,治疗方式和甲状腺激素水平 (TSH,FT4).
统计分析包括T测试,等级和测试,后勤回归,ROC曲线和Cox比例危险模型.

主要成果:

治疗前的因素,如吸烟史,甲状腺结节和宫淋巴结转移,与甲状腺功能障碍的风险更高有关.
81名患者在治疗期间出现甲状腺功能障碍.
与免疫疗法加化疗相比,抗PD-1免疫疗法和IMRT的结合导致甲状腺功能增强症的发病率和严重程度更高.

结论:

患有吸烟史,甲状腺结节或宫淋巴结转移的NPC患者在与IMRT结合的抗PD-1免疫疗法期间面临甲状腺功能障碍的风险增加.
同时使用抗PD-1免疫疗法和IMRT显著增加甲状腺功能障碍的发生和严重程度.
在接受免疫治疗的NPC患者中,放射治疗似乎会加剧与免疫相关的甲状腺不良反应.

关键词:

强度调节辐射疗法 (IMRT) 是一种强度调节辐射疗法.在PD-1中使用PD-1.鼻癌鼻癌鼻癌辐射疗法辐射疗法甲状腺功能障碍甲状腺功能障碍

更多相关视频

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.