增强的计算机化认知补救疗法改善了男性精神分裂症长期住院患者的认知功能,负面症状和GDNF
Peiyun Zhang1, Lingyun Chen1, Qianqian Qin1
1Laboratory of Biological Psychiatry, Nantong Mental Health Center, Nantong Brain Hospital & Affiliated Mental Health Center of Nantong University, Nantong, China.
Frontiers in psychiatry
|January 31, 2025
概括
计算机化认知补救疗法 (CCRT) 改善了精神分裂症患者的负面症状和认知功能. 这种疗法还帮助维持质细胞系衍生神经营养因子 (GDNF) 水平,这表明GDNF在治疗疗效方面发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 精神分裂症带来了负面和认知症状的重大挑战.
- 认知补救疗法 (CCRT) 为缓解症状提供了一个有希望的途径.
- 像BDNF和GDNF这样的神经损伤因子与认知功能和精神疾病有关.
研究的目的:
- 研究CCRT在改善精神病症状和精神分裂症患者认知缺陷方面的疗效.
- 检查CCRT对脑衍生神经变因子 (BDNF) 和质细胞系衍生神经变因子 (GDNF) 血清水平的影响.
- 探索认知改善,症状减轻和神经营养因子水平之间的关系.
主要方法:
- 40名男性,长期住院精神分裂症患者被随机分配到CCRT或对照组.
- CCRT组在8周内接受了40次会议,每周5次.
- 评估包括精神症状 (PANSS),认知 (MoCA,RBANS) 和血清BDNF/GDNF水平在基线,4周和8周.
主要成果:
- 与对照组相比,CCRT显著降低了整体和负症状得分 (PANSS).
- CCRT增强了认知表现,由改善的MoCA和RBANS得分证明.
- 清单回忆的改善与负面症状的减少相关,CCRT减轻了GDNF水平的下降.
结论:
- 在缓解精神分裂症的负面症状和认知缺陷方面,CCRT有效.
- 清单回忆的改善与CCRT在减少负面症状方面的有效性有关.
- 在精神分裂症患者中,GDNF可能在CCRT的治疗效果中发挥关键作用.
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