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免疫检查点抑制剂治疗后主要骨质疏松性骨折的增加

Carrie Ye¹, Bo Zhao², William D Leslie³

¹Medicine, University of Alberta, Edmonton, Alberta, Canada.

|January 31, 2025

概括

接受免疫检查点抑制剂 (ICI) 的患者面临更大的骨质疏松性骨折 (MOF) 风险. 这表明骨质疏松症和骨折可能是与ICI治疗相关的新的免疫相关不良事件.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
骨的新陈代谢骨的新陈代谢

背景情况:

免疫检查点抑制剂 (ICI) 可以导致严重的免疫相关不良事件 (irAEs).
来自ICI的增强免疫激活可能导致骨质细胞激活,骨损失和骨折.
这项研究旨在评估ICI治疗的黑色素瘤患者中严重骨质疏松性骨折 (MOF) 的发生率.

研究的目的:

评估用免疫检查点抑制剂 (ICI) 治疗黑色素瘤患者的主要骨质疏松性骨折 (MOF) 的发病率.

主要方法:

使用美国商业医疗保健索赔数据集进行了前后队列研究.
包括2011年至2022年接受ICI治疗的黑色素瘤成年患者.
在ICI启动之前和之后,使用ICD-9/10代码确定了MOF的发病率.

主要成果:

该队列包括3137名患者 (平均年龄68岁,64%是男性).
与ICI前 (1.3%) 相比,MOF发病率在ICI开始后增加 (1.8%在1年,1.8%在2年).
对MOF的危险比率为1.82 (第一年) 和1.85 (第二年) 在ICI后与ICI前. 之前的骨折,年龄较大,女性性别和联合ICI治疗增加了MOF风险.

结论:

接受ICI治疗的患者患MOF的风险较高.
骨质疏松症和骨质疏松性骨折可能是ICI治疗的新型irAE.
对ICI相关骨损失的机制和管理进行进一步的研究是有必要的.

关键词:

流行病学流行病学免疫治疗是一种免疫疗法.药物治疗药物治疗

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