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肠道失调与难以治疗的类风湿性关节炎有关
Patricia Ruiz-Limón1,2,3, Natalia Mena-Vázquez1,4, Isabel Moreno-Indias1,2,3
1The Biomedical Research Institute of Malaga and Platform in Nanomedicine (IBIMA BIONAND Platform), Málaga, Spain.
Frontiers in medicine
|January 31, 2025
概括
难以治疗的类风湿性关节炎 (D2T RA) 患者与易于治疗的类风湿性关节炎 (E2T RA) 患者相比,表现出不同的肠道微生物群组成和代谢概况. 这些肠道微生物群的差异可能会影响D2T RA的治疗耐药性.
科学领域:
- 微生物组研究 微生物组研究
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 难以治疗的类风湿性关节炎 (D2T RA) 被定义为疾病控制不足,尽管有多种b/tsDMARDs.
- 识别导致D2T RA的因素,例如肠道微生物群的改变,对于治疗进步至关重要.
- 这项研究将D2T RA患者的肠道微生物群和炎症与易于治疗的RA (E2T RA) 患者进行了比较.
研究的目的:
- 分析和比较D2T RA和E2T RA患者的肠道微生物群组成和功能.
- 确定与耐治疗的RA相关的特定微生物种群和代谢途径.
- 探索D2T RA中的肠道微生物群,炎症和临床因素之间的关系.
主要方法:
- 一个前性队列 (2007-2011) 的观察性研究,并对2022年进行分析.
- 肠道微生物群通过16S rRNA基因测序和PICRUSt进行功能推断进行分析.
- 记录了临床数据,炎症标志物 (DAS28-ESR),细胞因子和药物使用情况. 使用了考克斯多变量分析.
主要成果:
- 在D2T RA和E2T RA患者之间观察到肠道微生物群组成的显著差异.
- 像Megasphaera这样的丰富品种与D2T RA相关,而Coprococcus和Haemophilus在E2T RA中更为普遍.
- 较低的Firmicutes/Bacteroidetes比率,改变的代谢途径,更高的炎症活性和普雷尼松使用与D2T RA有关.
结论:
- 在D2T RA和E2T RA患者中,肠道微生物群的组成和功能显著不同.
- 特定的微生物变化和代谢途径可能导致RA治疗耐药性.
- 炎症活性,普雷尼松的使用,以及Firmicutes/Bacteroidetes的比率是与D2T RA相关的关键因素.
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