一项试点人类研究使用胺来治疗意识障碍
Paolo Cardone1,2, Arthur Bonhomme1, Vincent Bonhomme3,4
1Coma Science Group, GIGA-Consciousness, University of Liège, Liège, Belgium.
iScience
|January 31, 2025
概括
亚麻醉性胺可以改善大脑复杂性,并减少长期意识障碍 (DoC) 的患者的性. 这项研究探讨了胺.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 神经学 神经学
背景情况:
- 昏迷后意识障碍 (DoC) 的治疗选择有限.
- 迷幻药正在被探索,因为它们有可能增强DoC患者的大脑复杂性和意识.
- 胺,一种非典型的迷幻药,正在研究其治疗效果.
研究的目的:
- 为了研究亚麻醉剂胺对长期昏迷后意识障碍的影响.
- 评估大脑复杂性的变化,有意识的行为和性.
- 评估胺在这个患者群体中的安全性和耐受性.
主要方法:
- 这是一项双盲,安慰剂控制,交叉试验,涉及三名长期DoC的成年患者.
- 通过静脉注射增加度的胺和盐液.
- 持续的脑电图 (EEG) 记录,对有意识的行为进行评估,以及性.
主要成果:
- 胺注入增加了Lempel-Ziv复杂性 (LZC),这是大脑复杂性的衡量标准.
- 在可解释意识指标 (ECI) 中没有观察到显著变化.
- 患者表现出减少的性和增加的兴奋 (眼睛开放的持续时间);然而,诊断状态没有改善. 没有报告任何不良影响.
结论:
- 胺的使用可能会调节DoC患者的大脑复杂性.
- 氨酸在DoC中显示出降低性和增加兴奋的潜力.
- 需要进一步的研究来探索胺在意识障碍中的治疗作用.
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