进入矩阵:纤维细胞-免疫细胞相互作用塑造了健康和疾病中的细胞外矩阵沉积
Anthony Altieri1, Grace V Visser1, Matthew B Buechler1
1Immunology, University of Toronto, Toronto, Ontario, Canada.
F1000Research
|January 31, 2025
概括
纤维细胞通过改变细胞外基质 (ECM) 来塑造组织和免疫反应. 了解纤维细胞-ECM-免疫轴是开发纤维细胞疾病和癌症治疗方法的关键.
科学领域:
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
- 组织工程是组织工程.
背景情况:
- 纤维细胞是关键的介质细胞,构建组织并影响器官功能.
- 它们调节细胞外基质 (ECM),这是一个复杂的宏分子网络.
- 纤维细胞通过ECM分泌和结合分子调节免疫反应.
研究的目的:
- 审查纤维细胞衍生的ECM在调节组织结构和免疫反应方面的机制,重点关注巨细胞.
- 为了检查特定的纤维细胞衍生的ECM蛋白质,如原三环螺旋重复含有1 (CTHRC1) 和转化生长因子-β诱导蛋白 (TGFBI).
- 要突出研究不同纤维细胞种群如何通过ECM调节协调免疫反应的需要.
主要方法:
- 关于纤维细胞-ECM-免疫相互作用的最近研究的文献综述.
- 专注于涉及纤维细胞衍生ECM因子的机制及其对免疫细胞,特别是巨细胞的影响.
- 分析特定的ECM蛋白 (CTHRC1,TGFBI) 和它们的作用.
主要成果:
- 纤维细胞衍生的ECM显著塑造组织结构并影响免疫细胞的行为.
- 特定的ECM蛋白质,如CTHRC1和TGFBI,在这个轴中发挥关键作用.
- 纤维细胞-ECM-免疫轴内的复杂相互作用需要进一步阐明.
结论:
- 了解纤维细胞-ECM-免疫轴对于理解组织平衡和疾病至关重要.
- 研究多种纤维细胞种群及其ECM调制对于免疫协调至关重要.
- 识别ECM沉积的调节者对于纤维性疾病和癌症的新疗法策略至关重要.
相关概念视频
Introduction to Fibroblasts
3.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.0K
Extracellular Matrix
2.7K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
2.7K
The Extracellular Matrix
8.8K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
8.8K
Overview of Cell-Matrix Interactions
7.0K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
7.0K
Cell-matrix's Response to Mechanical Forces
2.5K
In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue.
Anchoring junctions mechanically attach a cell to the...
Anchoring junctions mechanically attach a cell to the...
2.5K
Fibronectins Connect Cells with ECM
2.3K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
2.3K


