多基因分数的关联和外部化行为发展轨迹的发展轨迹
A Brooke Sasia1,2,3, Katherine G Jonas4, Monika A Waszczuk5
1Department of Psychology, University of Wisconsin-Madison, Madison, WI, USA.
Development and psychopathology
|January 31, 2025
概括
多基因分数 (PGS) 预测外部化行为,但这项研究表明,它们对反社会行为和物质使用轨迹的长期性比绝对严重性更敏感. 这突显了PGS预测中的发育异质性.
科学领域:
- 精神病学和遗传学 精神病学和遗传学
- 发展心理学 发展心理学
- 行为科学 行为科学
背景情况:
- 多基因分数 (PGSs) 对预测精神病理学,包括外部化 (EXT) 行为,显示出希望.
- 以前的研究往往忽略了EXT结果中的复杂的发育和表型变异.
- 了解这些变异对于PGS的准确临床应用至关重要.
研究的目的:
- 调查EXT PGS与反社会行为 (ASB) 和物质使用行为 (SUB) 的不同发展轨迹之间的关联.
- 探索PGS是否能预测随着时间的推移行为发展的特定模式,并考虑异质性.
主要方法:
- 利用了从青少年到成人健康国家纵向研究 (N=4,416,年龄13-41) 的数据.
- 采用增长混合模型来确定ASB和SUB的轨迹.
- 检查了EXT PGS和这些已识别的行为轨迹之间的关联.
主要成果:
- 确定了四个ASB轨迹 (高衰退,中度,青春期峰值,低) 和三个SUB轨迹 (高使用,典型使用,低使用).
- EXT PGS与持续的ASB (高衰退) 和SUB (高使用) 轨迹有显著的关联.
- 此外,EXT PGS与低使用 SUB 轨迹也有关联,这表明了复杂的预测关系.
结论:
- PGS似乎对外化行为的发育类型学敏感.
- PGS的预测能力可能与行为慢性或持久性有关,而不仅仅是它们的绝对严重程度.
- 这些发现强调了在临床和研究环境中解释PGS时考虑发育异质性的重要性.
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