在SARS-CoV-2感染中进行嘴和鼻水的盐溶液的双盲随机试验
Sebastian R Espinoza1, Lexton Trauffler2, Amir Shamshirsaz3
1Trinity University, San Antonio, Texas, USA.
Journal of global health
|January 31, 2025
概括
低度和高度的盐水鼻水和水有效地减少了严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 症状持续时间. 这些盐水疗法还显著降低了SARS-CoV-2患者的住院率,与没有使用盐水相比.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 以前的研究表明,高血压盐水鼻灌和可以缩短上呼吸道感染症状的持续时间.
- 这项研究重点关注严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2).
研究的目的:
- 评估两种不同的盐水度对与SARS-CoV-2相关的症状的影响.
- 为了比较低盐和高盐的疗法在管理COVID-19症状的有效性.
主要方法:
- 成年人 (18-65岁) 患有SARS-CoV-2 (通过PCR确认) 被随机分配到低盐或高盐分组14天.
- 参与者每天四次用低盐 (2.13g盐/8oz水) 或高盐 (6g盐/8oz水) 盐溶液进行鼻水和嘴.
- 结果包括症状频率/持续时间,以及诸如住院治疗,机械通风或死亡率之类的二次结果. 为了进行比较,使用了大量的参考组 (9,398人).
主要成果:
- 在低度和高度组之间,没有发现症状频率或持续时间的显著差异.
- 与参考组相比,低盐度 (18.5%) 和高盐度 (21.4%) 组的住院率显着较低 (58.8%;P < 0.001).
- 在组间的其他次要结果中没有发现显著差异.
结论:
- 低盐和高盐的鼻子冲洗和嘴方案在缓解SARS-CoV-2症状方面表现出相似的有效性.
- 与不使用这些方法的人相比,用盐水灌鼻腔和嘴与感染SARS-CoV-2的个体的住院率降低有关.
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