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维护血管内皮功能在晚期出现的绝经后妇女

Sanna Darvish¹, Kevin O Murray¹, Katelyn R Ludwig¹

¹Department of Integrative Physiology, University of Colorado Boulder (S.D., K.O.M., K.R.L., K.H.A., D.H.C., K.A.F., D.R.S., M.J.R.).

Circulation research

|January 31, 2025

概括

晚期更年期通过减少氧化压力来保持内皮功能. 这与更健康的脂质代谢物有关,这可能解释了更晚更年期的女性心血管风险较低.

科学领域:

心血管健康心血管健康
内分泌学在内分泌学.
代谢学代谢学代谢学

背景情况:

晚期更年期 (55岁以上) 与正常开始的更年期 (45-54岁) 相比,与心血管疾病 (CVD) 风险的降低有关.
晚期更年期对血管内皮功能障碍及其潜在机制的影响仍然不清楚.

研究的目的:

为了研究晚期更年期对内皮功能的影响.
确定机制,特别是线粒体反应性氧物种 (mitoROS),将更年期的年龄与内皮功能联系起来.

主要方法:

在晚期开始的绝经后妇女 (PMW),正常开始的PMW和绝经前妇女中测量了内皮功能 (流介导扩张[FMD_BA).
评估了与mitROS相关的内皮功能障碍 (ΔFMD_BA,MTQ) 和血清对人类大动脉内皮细胞的影响.
利用代谢学来识别影响内皮细胞mitoROS生物活性的循环因素.

主要成果:

与正常发病的PMW相比,晚期发病的PMW表现出明显更高的FMD_BA (>50%) 和较低的米托罗斯相关功能障碍.
来自正常发作的PMW的血清,但不是晚期发作的PMW,在内皮细胞中增加了米托罗斯生物活性.
脂质代谢物,特别是三甘衍生的代谢物,如TG{16:0},有显著差异,与米托ROS生物活性相关.

结论:

晚期更年期与内皮功能的保存有关,这是由于较低的线粒激素的氧化应激减少.
良好的循环脂质特征,特别是甘油三,有助于在晚期发病的PMW中降低内皮细胞线粒ROS.
这些发现阐明了在经历过晚期绝经的女性中降低心血管疾病风险的机制.

关键词:

老化的老化衰老的老化它们的内皮质 (endothelium).脂质组的类型更年期绝经绝经线粒体中的线粒体.

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