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血骨质保护素和在缺血性中风后的认知障碍

Xinyue Chang¹, Pinni Yang¹, Yi Liu¹

¹Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.

Current neurovascular research

|January 31, 2025

概括

高血骨质保护素 (OPG) 水平与3个月内发生中风后认知障碍 (PSCI) 的风险增加有关. OPG可以作为一个有价值的生物标志物来预测中风后的PSCI.

科学领域:

神经学神经学
生物标志物生物标志物
脑卒中研究脑卒中研究

背景情况:

血骨质保护素 (OPG) 与中风预后不佳有关.
OPG对中风后认知障碍 (PSCI) 的影响尚不清楚.

研究的目的:

调查血OPG水平与PSCI之间的关系.
确定OPG是否可以作为中风后认知衰退的预测生物标志物.

主要方法:

包括613名缺血性中风患者,测量了血OPG水平.
使用迷你心理状态检查 (MMSE) 和蒙特利尔认知评估 (MoCA) 评估PSCI.
定义的PSCI为MMSE得分<25或MoCA得分<23.

主要成果:

最高的OPG三位数显示PSCI的几率增加了1.77倍 (95%CI1.09-2.89,P=0.021).
在血OPG和3个月的PSCI之间发现了正线性关联 (P=0.046).
在加上传统因素时,OPG改善了PSCI的风险重新分类.

结论:

血OPG水平升高与3个月PSCI的更高风险相关.
OPG展示了作为预测PSCI的有效生物标志物的潜力.
研究结果支持OPG在病理生理学或预测中风后认知障碍中的作用.

关键词:

缺血性中风是因为缺血性中风.生物标志物生物标志物认知障碍是一种认知障碍.迷你精神状态考试.精神状态考试.骨质保护剂中的骨质保护剂有关风险因素的风险因素.

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