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康复期血捐赠者和接受者的凝血概况

Hanna H Pitkänen^1,2,3, Tuukka Helin⁴, Tamim Khawaja^5,6,7,8

¹Helsinki University Hospital, Division of Anesthesiology, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

|January 31, 2025

概括

针对COVID-19的低滴度康复性等离子体 (LCP) 治疗增加了威尔布兰德因子抗原 (VWF:Ag) 的水平,并增强了血栓生成 (TG),表明比高滴度CP (HCP) 更大的高凝血能力. HCP可能与较少的前凝效应有关.

科学领域:

血液学血液学血液学
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

康复性血 (CP) 治疗COVID-19的疗法已经显示出可变的疗效,潜在的前凝剂效应引发了安全问题.
了解CP对凝血概况的影响对于优化其治疗用途至关重要.

研究的目的:

调查低位数 (LCP) 和高位数 (HCP) 康复性血对住院COVID-19患者的凝血概况的影响.

主要方法:

一个双盲随机试验,涉及54名接受安慰剂,LCP或HCP的患者.
在供体和受体血液样本中评估凝血生物标志物,抗脂抗体和血栓生成 (TG).
分析包括例行实验室检测,VWF:Ag水平,狼抗凝剂和内源性血栓潜力 (ETP).

主要成果:

与HP接收者相比,LCP接收者显示VWF:Ag水平增加和增强的TG (更高的ETP和高峰TG),尽管进行了血栓预防.
医疗保健专家组表现出较低的基线和第一天血小板计数比LCP组.
狼抗凝剂在所有组中的80%呈阳性.

结论:

低滴度康复性血 (LCP) 的使用增加了VWF:Ag并增强了血栓生成,表明更大的高凝血能力.
高滴度康复性血 (HCP) 似乎比LCP更少诱导高凝血能力.
这些发现可能解释了在COVID-19的CP治疗中观察到的可变疗效.

关键词:

在 COVID-19 疫情中,康复期间的血.血栓激素血栓激素是一种进行血栓预防.·威勒布兰德因素是什么

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